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KMID : 0903520000430010049
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2000 Volume.43 No. 1 p.49 ~ p.53
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In vitro Metabolism of Pyribenzoxim
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Kim, Ki Young
Kim, Jeong Han/Lee, Hye Suk/Kim, Jin/Liu, Kwang Hyeon
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Abstract
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The in vitro metabolism of a new herbicide pyribenzoxim, {benzophenone O-[2,6-bis[(4,6-dimethoxy-2-pyrimidinyl)oxy]benzoyl]oxime} was studied using rice, barnyardgrass and rat liver microsomes. No metabolism of pyribenzoxim was observed with rice and barnyardgrass microsomes although the cytochrome P450 was active, which was evidenced by the metabolism of cinnamic acid. With rat liver microsomes, four metabolites (M1, M2, M3, and M4) were produced while parent compound decreased. M1 and M2 were from the hydrolysis reactions and NADPH-dependent metabolites were M3 and M4 (major metabolite) which were hydroxylated by cytochrome P450. They were identified as bispyribacsodium (M1), benzophenone oxime (M2), {benzophenone O-[2,6-bis[(5-hydroxy-4,6-dimethoxy-2-pyrimidinyl)oxy]-benzoyl]oxime} (M3), and {benzophenone O-[2 [(5-hydroxy-4,6-dimethoxy-2-pyrimidinyl) 6-(4,6dimethoxy-2-pyrimidinyl)oxy]benzoyl]oxime} (M4) through LC/MS/MS analyses. Based on the results obtained metabolic map of pyribenzoxim is proposed.
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